5O4V
P.vivax NMT with aminomethylindazole and quinoline inhibitors bound
Summary for 5O4V
Entry DOI | 10.2210/pdb5o4v/pdb |
Related | 5O48 |
Descriptor | Glycylpeptide N-tetradecanoyltransferase, 2-oxopentadecyl-CoA, 1-[5-(4-fluoranyl-2-methyl-phenyl)-1~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, ... (9 entities in total) |
Functional Keywords | transferase, inhibitor, myristoyl |
Biological source | Plasmodium vivax |
Total number of polymer chains | 3 |
Total formula weight | 140490.20 |
Authors | Brannigan, J.A.,Wilkinson, A.J. (deposition date: 2017-05-31, release date: 2018-05-16, Last modification date: 2024-01-17) |
Primary citation | Mousnier, A.,Bell, A.S.,Swieboda, D.P.,Morales-Sanfrutos, J.,Perez-Dorado, I.,Brannigan, J.A.,Newman, J.,Ritzefeld, M.,Hutton, J.A.,Guedan, A.,Asfor, A.S.,Robinson, S.W.,Hopkins-Navratilova, I.,Wilkinson, A.J.,Johnston, S.L.,Leatherbarrow, R.J.,Tuthill, T.J.,Solari, R.,Tate, E.W. Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. Nat Chem, 10:599-606, 2018 Cited by PubMed: 29760414DOI: 10.1038/s41557-018-0039-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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