5O3I

Human Brd2(BD2) mutant in complex with AL-tBu

5O3I の概要

• エントリーDOI: 10.2210/pdb5o3i/pdb
• 分子名称: Bromodomain-containing protein 2, ~{tert}-butyl (2~{R})-2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]pent-4-enoate, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: the bromodomain and extra-terminal domain (bet) family chromatin binding protein, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14024.01

構造登録者

Chan, K.-H.,Runcie, A.C.,Ciulli, A. (登録日: 2017-05-23, 公開日: 2018-02-14, 最終更新日: 2024-01-17)

• 主引用文献: Runcie, A.C.,Zengerle, M.,Chan, K.H.,Testa, A.,van Beurden, L.,Baud, M.G.J.,Epemolu, O.,Ellis, L.C.J.,Read, K.D.,Coulthard, V.,Brien, A.,Ciulli, A.; Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition.; Chem Sci, 9:2452-2468, 2018; PubMed: 29732121; DOI: 10.1039/c7sc02536j

実験手法

X-RAY DIFFRACTION (1.2 Å)