5O2D

PARP14 Macrodomain 2 with inhibitor

Summary for 5O2D

Entry DOI	10.2210/pdb5o2d/pdb
Descriptor	Poly [ADP-ribose] polymerase 14, ~{N}-[2-(9~{H}-carbazol-1-yl)phenyl]methanesulfonamide (3 entities in total)
Functional Keywords	parp, adp-ribose, structural genomics, structural genomics consortium, sgc, adp-ribose-binding-protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	21929.90
Authors	Uth, K.,Schuller, M.,Sieg, C.,Wang, J.,Krojer, T.,Knapp, S.,Riedels, K.,Bracher, F.,Edwards, A.M.,Arrowsmith, C.,Bountra, C.,Elkins, J.M.,Structural Genomics Consortium (SGC) (deposition date: 2017-05-20, release date: 2017-11-08, Last modification date: 2024-05-08)
Primary citation	Schuller, M.,Riedel, K.,Gibbs-Seymour, I.,Uth, K.,Sieg, C.,Gehring, A.P.,Ahel, I.,Bracher, F.,Kessler, B.M.,Elkins, J.M.,Knapp, S. Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. ACS Chem. Biol., 12:2866-2874, 2017 Cited by PubMed: 28991428 DOI: 10.1021/acschembio.7b00445 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation