5O1C
p53 cancer mutant Y220C in complex with compound MB184
Summary for 5O1C
Entry DOI | 10.2210/pdb5o1c/pdb |
Descriptor | Cellular tumor antigen p53, ZINC ION, 5-(4-fluorophenyl)-3-iodanyl-2-oxidanyl-4-pyrrol-1-yl-benzoic acid, ... (4 entities in total) |
Functional Keywords | p53, tumor suppressor, cancer mutation, protein stabilization, small-molecule stabilizers, cancer therapy, dna binding protein, molecular chaperones |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 2 |
Total formula weight | 50038.79 |
Authors | Joerger, A.C.,Baud, M.G.J.,Bauer, M.R.,Fersht, A.R. (deposition date: 2017-05-18, release date: 2018-05-09, Last modification date: 2024-01-17) |
Primary citation | Baud, M.G.J.,Bauer, M.R.,Verduci, L.,Dingler, F.A.,Patel, K.J.,Horil Roy, D.,Joerger, A.C.,Fersht, A.R. Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem, 152:101-114, 2018 Cited by PubMed: 29702446DOI: 10.1016/j.ejmech.2018.04.035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.32 Å) |
Structure validation
Download full validation report