5O1C

p53 cancer mutant Y220C in complex with compound MB184

5O1C の概要

• エントリーDOI: 10.2210/pdb5o1c/pdb
• 分子名称: Cellular tumor antigen p53, ZINC ION, 5-(4-fluorophenyl)-3-iodanyl-2-oxidanyl-4-pyrrol-1-yl-benzoic acid, ... (4 entities in total)
• 機能のキーワード: p53, tumor suppressor, cancer mutation, protein stabilization, small-molecule stabilizers, cancer therapy, dna binding protein, molecular chaperones
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50038.79

構造登録者

Joerger, A.C.,Baud, M.G.J.,Bauer, M.R.,Fersht, A.R. (登録日: 2017-05-18, 公開日: 2018-05-09, 最終更新日: 2024-01-17)

• 主引用文献: Baud, M.G.J.,Bauer, M.R.,Verduci, L.,Dingler, F.A.,Patel, K.J.,Horil Roy, D.,Joerger, A.C.,Fersht, A.R.; Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.; Eur J Med Chem, 152:101-114, 2018; PubMed: 29702446; DOI: 10.1016/j.ejmech.2018.04.035

実験手法

X-RAY DIFFRACTION (1.32 Å)