5NZZ
Crystal structure of phosphorylated p38aMAPK in complex with TAB1
Summary for 5NZZ
Entry DOI | 10.2210/pdb5nzz/pdb |
Descriptor | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase 14, NICKEL (II) ION, ... (6 entities in total) |
Functional Keywords | mapk activated phosphorylated p38 regulation, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 387382.88 |
Authors | Nichols, C.E.,De Nicola, G.F. (deposition date: 2017-05-15, release date: 2018-05-30, Last modification date: 2018-09-19) |
Primary citation | De Nicola, G.F.,Bassi, R.,Nichols, C.,Fernandez-Caggiano, M.,Golforoush, P.A.,Thapa, D.,Anderson, R.,Martin, E.D.,Verma, S.,Kleinjung, J.,Laing, A.,Hutchinson, J.P.,Eaton, P.,Clark, J.,Marber, M.S. The TAB1-p38 alpha complex aggravates myocardial injury and can be targeted by small molecules. JCI Insight, 3:-, 2018 Cited by PubMed: 30135318DOI: 10.1172/jci.insight.121144 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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