5NZZ

Crystal structure of phosphorylated p38aMAPK in complex with TAB1

5NZZ の概要

• エントリーDOI: 10.2210/pdb5nzz/pdb
• 分子名称: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase 14, NICKEL (II) ION, ... (6 entities in total)
• 機能のキーワード: mapk activated phosphorylated p38 regulation, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 387382.88

構造登録者

Nichols, C.E.,De Nicola, G.F. (登録日: 2017-05-15, 公開日: 2018-05-30, 最終更新日: 2018-09-19)

• 主引用文献: De Nicola, G.F.,Bassi, R.,Nichols, C.,Fernandez-Caggiano, M.,Golforoush, P.A.,Thapa, D.,Anderson, R.,Martin, E.D.,Verma, S.,Kleinjung, J.,Laing, A.,Hutchinson, J.P.,Eaton, P.,Clark, J.,Marber, M.S.; The TAB1-p38 alpha complex aggravates myocardial injury and can be targeted by small molecules.; JCI Insight, 3:-, 2018; PubMed: 30135318; DOI: 10.1172/jci.insight.121144

実験手法

X-RAY DIFFRACTION (2.6 Å)