5NWH

Potent inhibitors of NUDT5 silence hormone signaling in breast cancer

Summary for 5NWH

Entry DOI	10.2210/pdb5nwh/pdb
Descriptor	ADP-sugar pyrophosphatase, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-piperazin-1-yl-purine-2,6-dione (3 entities in total)
Functional Keywords	nudix, inhibitor, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	49693.85
Authors	Carter, M.,Stenmark, P. (deposition date: 2017-05-06, release date: 2018-04-04, Last modification date: 2024-01-17)
Primary citation	Page, B.D.G.,Valerie, N.C.K.,Wright, R.H.G.,Wallner, O.,Isaksson, R.,Carter, M.,Rudd, S.G.,Loseva, O.,Jemth, A.S.,Almlof, I.,Font-Mateu, J.,Llona-Minguez, S.,Baranczewski, P.,Jeppsson, F.,Homan, E.,Almqvist, H.,Axelsson, H.,Regmi, S.,Gustavsson, A.L.,Lundback, T.,Scobie, M.,Stromberg, K.,Stenmark, P.,Beato, M.,Helleday, T. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nat Commun, 9:250-250, 2018 Cited by PubMed: 29343827 DOI: 10.1038/s41467-017-02293-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation