5NWH

Potent inhibitors of NUDT5 silence hormone signaling in breast cancer

5NWH の概要

• エントリーDOI: 10.2210/pdb5nwh/pdb
• 分子名称: ADP-sugar pyrophosphatase, 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-piperazin-1-yl-purine-2,6-dione (3 entities in total)
• 機能のキーワード: nudix, inhibitor, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49693.85

構造登録者

Carter, M.,Stenmark, P. (登録日: 2017-05-06, 公開日: 2018-04-04, 最終更新日: 2024-01-17)

• 主引用文献: Page, B.D.G.,Valerie, N.C.K.,Wright, R.H.G.,Wallner, O.,Isaksson, R.,Carter, M.,Rudd, S.G.,Loseva, O.,Jemth, A.S.,Almlof, I.,Font-Mateu, J.,Llona-Minguez, S.,Baranczewski, P.,Jeppsson, F.,Homan, E.,Almqvist, H.,Axelsson, H.,Regmi, S.,Gustavsson, A.L.,Lundback, T.,Scobie, M.,Stromberg, K.,Stenmark, P.,Beato, M.,Helleday, T.; Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.; Nat Commun, 9:250-250, 2018; PubMed: 29343827; DOI: 10.1038/s41467-017-02293-7

実験手法

X-RAY DIFFRACTION (2.6 Å)