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5NVZ

pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(1-acetylcyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 16)

Summary for 5NVZ
Entry DOI10.2210/pdb5nvz/pdb
DescriptorElongin-B, Elongin-C, Von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
Functional Keywordsprotein complex, ubiquitin ligase, hypoxia inducible factor, ligase
Biological sourceHomo sapiens (Human)
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Cellular locationNucleus : Q15370 Q15369
Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337
Total number of polymer chains12
Total formula weight169111.74
Authors
Gadd, M.S.,Soares, P.,Ciulli, A. (deposition date: 2017-05-04, release date: 2017-09-20, Last modification date: 2024-01-17)
Primary citationSoares, P.,Gadd, M.S.,Frost, J.,Galdeano, C.,Ellis, L.,Epemolu, O.,Rocha, S.,Read, K.D.,Ciulli, A.
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
J. Med. Chem., 61:599-618, 2018
Cited by
PubMed: 28853884
DOI: 10.1021/acs.jmedchem.7b00675
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

건을2024-03-27부터공개중

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