5NVO
Human DNMT3B PWWP domain in complex with choline
Summary for 5NVO
Entry DOI | 10.2210/pdb5nvo/pdb |
Descriptor | DNA (cytosine-5)-methyltransferase 3B, CHOLINE ION, SULFATE ION, ... (4 entities in total) |
Functional Keywords | dnmt3b pwwp domain, histone binding, beta barrel, ligand, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 34470.60 |
Authors | Rondelet, G.,Wouters, J. (deposition date: 2017-05-04, release date: 2018-05-30, Last modification date: 2024-01-17) |
Primary citation | Rondelet, G.,Dal Maso, T.,Maniquet, A.,Themans, Q.,Wouters, J. Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors To be published, |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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