5NUU
Torpedo californica acetylcholinesterase in complex with a chlorotacrine-tryptophan hybrid inhibitor
Summary for 5NUU
Entry DOI | 10.2210/pdb5nuu/pdb |
Descriptor | Acetylcholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | alzheimer's disease, tacrine, acetylcholinesterase, acetylcholiensterase inhibitor, hydrolase |
Biological source | Tetronarce californica (Pacific electric ray) |
Total number of polymer chains | 1 |
Total formula weight | 63707.90 |
Authors | Caliandro, R.,Pesaresi, A.,Lamba, D. (deposition date: 2017-05-02, release date: 2018-05-30, Last modification date: 2024-01-17) |
Primary citation | Chalupova, K.,Korabecny, J.,Bartolini, M.,Monti, B.,Lamba, D.,Caliandro, R.,Pesaresi, A.,Brazzolotto, X.,Gastellier, A.J.,Nachon, F.,Pejchal, J.,Jarosova, M.,Hepnarova, V.,Jun, D.,Hrabinova, M.,Dolezal, R.,Zdarova Karasova, J.,Mzik, M.,Kristofikova, Z.,Misik, J.,Muckova, L.,Jost, P.,Soukup, O.,Benkova, M.,Setnicka, V.,Habartova, L.,Chvojkova, M.,Kleteckova, L.,Vales, K.,Mezeiova, E.,Uliassi, E.,Valis, M.,Nepovimova, E.,Bolognesi, M.L.,Kuca, K. Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease. Eur.J.Med.Chem., 168:491-514, 2019 Cited by PubMed: 30851693DOI: 10.1016/j.ejmech.2019.02.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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