5NUU

Torpedo californica acetylcholinesterase in complex with a chlorotacrine-tryptophan hybrid inhibitor

5NUU の概要

• エントリーDOI: 10.2210/pdb5nuu/pdb
• 分子名称: Acetylcholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: alzheimer's disease, tacrine, acetylcholinesterase, acetylcholiensterase inhibitor, hydrolase
• 由来する生物種: Tetronarce californica (Pacific electric ray)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63707.90

構造登録者

Caliandro, R.,Pesaresi, A.,Lamba, D. (登録日: 2017-05-02, 公開日: 2018-05-30, 最終更新日: 2024-01-17)

• 主引用文献: Chalupova, K.,Korabecny, J.,Bartolini, M.,Monti, B.,Lamba, D.,Caliandro, R.,Pesaresi, A.,Brazzolotto, X.,Gastellier, A.J.,Nachon, F.,Pejchal, J.,Jarosova, M.,Hepnarova, V.,Jun, D.,Hrabinova, M.,Dolezal, R.,Zdarova Karasova, J.,Mzik, M.,Kristofikova, Z.,Misik, J.,Muckova, L.,Jost, P.,Soukup, O.,Benkova, M.,Setnicka, V.,Habartova, L.,Chvojkova, M.,Kleteckova, L.,Vales, K.,Mezeiova, E.,Uliassi, E.,Valis, M.,Nepovimova, E.,Bolognesi, M.L.,Kuca, K.; Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.; Eur.J.Med.Chem., 168:491-514, 2019; PubMed: 30851693; DOI: 10.1016/j.ejmech.2019.02.021

実験手法

X-RAY DIFFRACTION (2.5 Å)