5NTP

Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds

5NTP の概要

• エントリーDOI: 10.2210/pdb5ntp/pdb
• 分子名称: Nuclear receptor ROR-gamma, (S)-N-(5-chloro-3-((4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl)methyl)-2-methylphenyl)-2-methylpyrimidine-5-carboxamide (3 entities in total)
• 機能のキーワード: nuclear hormone receptor, ligand-binding domain, inverse agonist, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28099.95

構造登録者

Kallen, J. (登録日: 2017-04-28, 公開日: 2017-06-21, 最終更新日: 2024-01-17)

• 主引用文献: Kallen, J.,Izaac, A.,Be, C.,Arista, L.,Orain, D.,Kaupmann, K.,Guntermann, C.,Hoegenauer, K.,Hintermann, S.; Structural States of ROR gamma t: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds.; ChemMedChem, 12:1014-1021, 2017; PubMed: 28590087; DOI: 10.1002/cmdc.201700278

実験手法

X-RAY DIFFRACTION (1.7 Å)