5NTK

Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds

5NTK の概要

• エントリーDOI: 10.2210/pdb5ntk/pdb
• 分子名称: Nuclear receptor ROR-gamma, [(3~{S},8~{S},9~{S},10~{R},13~{R},14~{S},17~{R})-10,13-dimethyl-17-[(2~{R})-5-[[4-(2-morpholin-4-ylethoxy)phenyl]methylamino]-5-oxidanylidene-pentan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1~{H}-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate (3 entities in total)
• 機能のキーワード: nuclear hormone receptor, ligand-binding domain, inverse agonist, nuclear protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P51449
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54953.72

構造登録者

Kallen, J. (登録日: 2017-04-28, 公開日: 2017-06-21, 最終更新日: 2024-01-17)

• 主引用文献: Kallen, J.,Izaac, A.,Be, C.,Arista, L.,Orain, D.,Kaupmann, K.,Guntermann, C.,Hoegenauer, K.,Hintermann, S.; Structural States of ROR gamma t: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds.; ChemMedChem, 12:1014-1021, 2017; PubMed: 28590087; DOI: 10.1002/cmdc.201700278

実験手法

X-RAY DIFFRACTION (1.9 Å)