5NT1
Complex of influenza A NS1 effector domain with TRIM25 coiled coil
Summary for 5NT1
Entry DOI | 10.2210/pdb5nt1/pdb |
Descriptor | E3 ubiquitin/ISG15 ligase TRIM25, Non-structural protein 1 (3 entities in total) |
Functional Keywords | viral protein/host protein, ligase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : Q14258 Host nucleus : P03496 |
Total number of polymer chains | 6 |
Total formula weight | 117289.85 |
Authors | Koliopoulos, M.G.,Rittinger, K. (deposition date: 2017-04-27, release date: 2018-05-16, Last modification date: 2024-01-17) |
Primary citation | Koliopoulos, M.G.,Lethier, M.,van der Veen, A.G.,Haubrich, K.,Hennig, J.,Kowalinski, E.,Stevens, R.V.,Martin, S.R.,Reis E Sousa, C.,Cusack, S.,Rittinger, K. Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition. Nat Commun, 9:1820-1820, 2018 Cited by PubMed: 29739942DOI: 10.1038/s41467-018-04214-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.82 Å) |
Structure validation
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