5NSG

Fc DEDE homodimer variant

5NSG の概要

• エントリーDOI: 10.2210/pdb5nsg/pdb
• 分子名称: Putative uncharacterized protein DKFZp686C11235, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total)
• 機能のキーワード: igg, fc homodimer, l351d/l368e + l351d/l368e, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27691.96

構造登録者

De Nardis, C.,Hendriks, L.J.A.,Poirier, E.,Arvinte, T.,Gros, P.,Bakker, A.B.H.,de Kruif, J. (登録日: 2017-04-26, 公開日: 2017-07-05, 最終更新日: 2024-01-17)

• 主引用文献: De Nardis, C.,Hendriks, L.J.A.,Poirier, E.,Arvinte, T.,Gros, P.,Bakker, A.B.H.,de Kruif, J.; A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.; J. Biol. Chem., 292:14706-14717, 2017; PubMed: 28655766; DOI: 10.1074/jbc.M117.793497

実験手法

X-RAY DIFFRACTION (2.22 Å)