5NRD

A Native Ternary Complex of Alpha-1,3-Galactosyltransferase (a-3GalT) Supports a Conserved Reaction Mechanism for Retaining Glycosyltransferases - alpha-3GalT in complex with Co2+, UDP-Gal and lactose - a3GalT-Co2+-UDP-Gal-LAT-2

5NRD の概要

• エントリーDOI: 10.2210/pdb5nrd/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900004
• 分子名称: N-acetyllactosaminide alpha-1,3-galactosyltransferase, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, COBALT (II) ION, ... (6 entities in total)
• 機能のキーワード: glycosyltransferase, gta, transferase
• 由来する生物種: Bos taurus (Bovine)
• 細胞内の位置: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P14769
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70415.85

構造登録者

Albesa-Jove, D.,Marina, A.,Sainz-Polo, M.A.,Guerin, M.E. (登録日: 2017-04-22, 公開日: 2017-10-11, 最終更新日: 2024-01-17)

• 主引用文献: Albesa-Jove, D.,Sainz-Polo, M.A.,Marina, A.,Guerin, M.E.; Structural Snapshots of alpha-1,3-Galactosyltransferase with Native Substrates: Insight into the Catalytic Mechanism of Retaining Glycosyltransferases.; Angew. Chem. Int. Ed. Engl., 56:14853-14857, 2017; PubMed: 28960760; DOI: 10.1002/anie.201707922

実験手法

X-RAY DIFFRACTION (2.12 Å)