5NPS

The human O-GlcNAc transferase in complex with a bisubstrate inhibitor

5NPS の概要

• エントリーDOI: 10.2210/pdb5nps/pdb
• 分子名称: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] propyl hydrogen phosphate, ... (4 entities in total)
• 機能のキーワード: o-glcnac transferase, gt-b, gt41, rossman-fold, active site, inhibitor, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81717.10

構造登録者

Rafie, K.,van Aalten, D. (登録日: 2017-04-18, 公開日: 2018-05-16, 最終更新日: 2023-03-15)

• 主引用文献: Rafie, K.,Gorelik, A.,Trapannone, R.,Borodkin, V.S.,van Aalten, D.M.F.; Thio-Linked UDP-Peptide Conjugates as O-GlcNAc Transferase Inhibitors.; Bioconjug. Chem., 29:1834-1840, 2018; PubMed: 29723473; DOI: 10.1021/acs.bioconjchem.8b00194

実験手法

X-RAY DIFFRACTION (1.68 Å)