5NPK
1.98A STRUCTURE OF THIOPHENE1 WITH S.AUREUS DNA GYRASE AND DNA
Summary for 5NPK
Entry DOI | 10.2210/pdb5npk/pdb |
Descriptor | DNA gyrase subunit B,DNA gyrase subunit B,DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), MANGANESE (II) ION, ... (10 entities in total) |
Functional Keywords | type iia topoisomerase, antibacterial, inhibitor, isomerase |
Biological source | Staphylococcus aureus More |
Total number of polymer chains | 8 |
Total formula weight | 341501.87 |
Authors | Bax, B.D.,Chan, P.F.,Stavenger, R.A. (deposition date: 2017-04-17, release date: 2017-07-12, Last modification date: 2018-10-24) |
Primary citation | Chan, P.F.,Germe, T.,Bax, B.D.,Huang, J.,Thalji, R.K.,Bacque, E.,Checchia, A.,Chen, D.,Cui, H.,Ding, X.,Ingraham, K.,McCloskey, L.,Raha, K.,Srikannathasan, V.,Maxwell, A.,Stavenger, R.A. Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase. Proc. Natl. Acad. Sci. U.S.A., 114:E4492-E4500, 2017 Cited by PubMed: 28507124DOI: 10.1073/pnas.1700721114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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