5NP8

PGK1 in complex with CRT0063465 (3-[2-(4-bromophenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]propanoic acid)

5NP8 の概要

• エントリーDOI: 10.2210/pdb5np8/pdb
• 分子名称: Phosphoglycerate kinase 1, 3-[2-(4-bromophenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]propanoic acid, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45701.39

構造登録者

Turnbull, A.P.,Bilsland, A.E.,Liu, Y.,Sumpton, D.,Stevenson, K.,Cairney, C.J.,Roffey, J.,Jenkinson, D.,Keith, W.N. (登録日: 2017-04-13, 公開日: 2018-05-16, 最終更新日: 2024-01-17)

• 主引用文献: Bilsland, A.E.,Liu, Y.,Turnbull, A.,Sumpton, D.,Stevenson, K.,Cairney, C.J.,Boyd, S.M.,Roffey, J.,Jenkinson, D.,Keith, W.N.; A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation.; Neoplasia, 21:893-907, 2019; PubMed: 31401411; DOI: 10.1016/j.neo.2019.07.008

実験手法

X-RAY DIFFRACTION (1.9 Å)