5NNE

Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated TOP2A peptide (K1201ac/K1204ac)

Summary for 5NNE

Entry DOI	10.2210/pdb5nne/pdb
Descriptor	Bromodomain-containing protein 4, GKA(ALY)GK(ALY)TQMY, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	bromodomain, transcription, complex
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	16487.02
Authors	Filippakopoulos, P.,Picaud, S.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C. (deposition date: 2017-04-08, release date: 2018-05-16, Last modification date: 2024-01-17)
Primary citation	Lambert, J.P.,Picaud, S.,Fujisawa, T.,Hou, H.,Savitsky, P.,Uuskula-Reimand, L.,Gupta, G.D.,Abdouni, H.,Lin, Z.Y.,Tucholska, M.,Knight, J.D.R.,Gonzalez-Badillo, B.,St-Denis, N.,Newman, J.A.,Stucki, M.,Pelletier, L.,Bandeira, N.,Wilson, M.D.,Filippakopoulos, P.,Gingras, A.C. Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol. Cell, 73:621-638.e17, 2019 Cited by PubMed: 30554943 DOI: 10.1016/j.molcel.2018.11.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.15 Å)

Structure validation