5NND

Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)

5NND の概要

• エントリーDOI: 10.2210/pdb5nnd/pdb
• 分子名称: Bromodomain-containing protein 4, Histone H3, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bromodomain, transcription, complex
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 34407.33

構造登録者

Filippakopoulos, P.,Picaud, S.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C. (登録日: 2017-04-08, 公開日: 2018-05-16, 最終更新日: 2024-01-17)

• 主引用文献: Lambert, J.P.,Picaud, S.,Fujisawa, T.,Hou, H.,Savitsky, P.,Uuskula-Reimand, L.,Gupta, G.D.,Abdouni, H.,Lin, Z.Y.,Tucholska, M.,Knight, J.D.R.,Gonzalez-Badillo, B.,St-Denis, N.,Newman, J.A.,Stucki, M.,Pelletier, L.,Bandeira, N.,Wilson, M.D.,Filippakopoulos, P.,Gingras, A.C.; Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.; Mol. Cell, 73:621-638.e17, 2019; PubMed: 30554943; DOI: 10.1016/j.molcel.2018.11.006

実験手法

X-RAY DIFFRACTION (1.82 Å)