5NN6
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with N-hydroxyethyl-1-deoxynojirimycin
Summary for 5NN6
| Entry DOI | 10.2210/pdb5nn6/pdb |
| Related | 5NN3 5NN4 5NN5 |
| Descriptor | Lysosomal alpha-glucosidase, TRIETHYLENE GLYCOL, GLYCEROL, ... (12 entities in total) |
| Functional Keywords | glycoside hydrolase, lysosome, glycogen catabolism, pompe disease, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 101829.62 |
| Authors | Roig-Zamboni, V.,Cobucci-Ponzano, B.,Iacono, R.,Ferrara, M.C.,Germany, S.,Parenti, G.,Bourne, Y.,Moracci, M. (deposition date: 2017-04-08, release date: 2017-10-25, Last modification date: 2024-01-17) |
| Primary citation | Roig-Zamboni, V.,Cobucci-Ponzano, B.,Iacono, R.,Ferrara, M.C.,Germany, S.,Bourne, Y.,Parenti, G.,Moracci, M.,Sulzenbacher, G. Structure of human lysosomal acid alpha-glucosidase-a guide for the treatment of Pompe disease. Nat Commun, 8:1111-1111, 2017 Cited by PubMed: 29061980DOI: 10.1038/s41467-017-01263-3 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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