5NKN

Crystal structure of an Anticalin-colchicine complex

5NKN の概要

• エントリーDOI: 10.2210/pdb5nkn/pdb
• 分子名称: Neutrophil gelatinase-associated lipocalin, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide (3 entities in total)
• 機能のキーワード: beta-barrel, colchicine, lcn2, lipocalin, ngal, protein engineering, transport protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20342.14

構造登録者

Skerra, A.,Eichinger, A.,Barkovskiy, M. (登録日: 2017-03-31, 公開日: 2018-04-04, 最終更新日: 2024-01-17)

• 主引用文献: Barkovskiy, M.,Ilyukhina, E.,Dauner, M.,Eichinger, A.,Skerra, A.; An engineered lipocalin that tightly complexes the plant poison colchicine for use as antidote and in bioanalytical applications.; Biol. Chem., 400:351-366, 2019; PubMed: 30517073; DOI: 10.1515/hsz-2018-0342

実験手法

X-RAY DIFFRACTION (2.2 Å)