5NKH

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 3e

Summary for 5NKH

Entry DOI	10.2210/pdb5nkh/pdb
Descriptor	Ephrin type-A receptor 2, 2-[[3-(2-aminophenyl)-5-(piperidin-4-ylcarbamoyl)phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide (3 entities in total)
Functional Keywords	inhibitor, complex, protein tyrosine kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35023.94
Authors	Kudlinzki, D.,Linhard, V.L.,Witt, K.,Gande, S.L.,Saxena, K.,Heinzlmeir, S.,Medard, G.,Kuester, B.,Schwalbe, H. (deposition date: 2017-03-31, release date: 2017-06-07, Last modification date: 2024-01-17)
Primary citation	Heinzlmeir, S.,Lohse, J.,Treiber, T.,Kudlinzki, D.,Linhard, V.,Gande, S.L.,Sreeramulu, S.,Saxena, K.,Liu, X.,Wilhelm, M.,Schwalbe, H.,Kuster, B.,Medard, G. Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors. ChemMedChem, 12:999-1011, 2017 Cited by PubMed: 28544567 DOI: 10.1002/cmdc.201700217 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.29 Å)

Structure validation