5NJK
PTB domain of human Numb isoform-1
Summary for 5NJK
Entry DOI | 10.2210/pdb5njk/pdb |
Descriptor | Protein numb homolog, ALA-TYR-ILE-GLY-PRO-PTR-LEU, SULFATE ION, ... (4 entities in total) |
Functional Keywords | ptb domain, numb, breast cancer, endocytosis |
Biological source | Homo sapiens (Human) More |
Cellular location | Membrane; Peripheral membrane protein: P49757 |
Total number of polymer chains | 12 |
Total formula weight | 113013.58 |
Authors | Mapelli, M.,Di Fiore, P.P. (deposition date: 2017-03-29, release date: 2017-12-13, Last modification date: 2024-01-17) |
Primary citation | Colaluca, I.N.,Basile, A.,Freiburger, L.,D'Uva, V.,Disalvatore, D.,Vecchi, M.,Confalonieri, S.,Tosoni, D.,Cecatiello, V.,Malabarba, M.G.,Yang, C.J.,Kainosho, M.,Sattler, M.,Mapelli, M.,Pece, S.,Di Fiore, P.P. A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer. J. Cell Biol., 217:745-762, 2018 Cited by PubMed: 29269425DOI: 10.1083/jcb.201709092 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.13 Å) |
Structure validation
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