5NIU

Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor

5NIU の概要

• エントリーDOI: 10.2210/pdb5niu/pdb
• 分子名称: Programmed cell death 1 ligand 1, (2~{R})-2-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-5-methyl-phenyl]methylamino]-3-oxidanyl-propanoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: pd-l1, pd-1, immune checkpoint, immune system
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform 1: Cell membrane ; Single-pass type I membrane protein . Isoform 2: Endomembrane system ; Single-pass type I membrane protein : Q9NZQ7
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 60028.48

構造登録者

Zak, K.M.,Grudnik, P.,Skalniak, L.,Dubin, G.,Holak, T.A. (登録日: 2017-03-27, 公開日: 2017-12-06, 最終更新日: 2024-01-17)

• 主引用文献: Skalniak, L.,Zak, K.M.,Guzik, K.,Magiera, K.,Musielak, B.,Pachota, M.,Szelazek, B.,Kocik, J.,Grudnik, P.,Tomala, M.,Krzanik, S.,Pyrc, K.,Domling, A.,Dubin, G.,Holak, T.A.; Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.; Oncotarget, 8:72167-72181, 2017; PubMed: 29069777; DOI: 10.18632/oncotarget.20050

実験手法

X-RAY DIFFRACTION (2.01 Å)