5NIK

Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump

Summary for 5NIK

• Entry DOI: 10.2210/pdb5nik/pdb
• EMDB information: 3652
• Descriptor: Outer membrane protein TolC, Macrolide export protein MacA, Macrolide export ATP-binding/permease protein MacB (3 entities in total)
• Functional Keywords: abc transporter, drug efflux pump, multi-drug resistance, macrolide transporter, toxin transporter, transport protein
• Biological source: Escherichia coli (strain K12); More
• Total number of polymer chains: 11
• Total formula weight: 545014.30

Authors

Fitzpatrick, A.W.P.,Llabres, S.,Neuberger, A.,Blaza, J.N.,Bai, X.-C.,Okada, U.,Murakami, S.,van Veen, H.W.,Zachariae, U.,Scheres, S.H.W.,Luisi, B.F.,Du, D. (deposition date: 2017-03-24, release date: 2017-05-24, Last modification date: 2019-10-23)

• Primary citation: Fitzpatrick, A.W.P.,Llabres, S.,Neuberger, A.,Blaza, J.N.,Bai, X.C.,Okada, U.,Murakami, S.,van Veen, H.W.,Zachariae, U.,Scheres, S.H.W.,Luisi, B.F.,Du, D.; Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump.; Nat Microbiol, 2:17070-17070, 2017; PubMed: 28504659; DOI: 10.1038/nmicrobiol.2017.70

Experimental method

ELECTRON MICROSCOPY (3.3 Å)