5NIB

Ligand complex of RORg LBD

5NIB の概要

• エントリーDOI: 10.2210/pdb5nib/pdb
• 分子名称: Nuclear receptor ROR-gamma, The tethered SRC2-2 peptide, ~{N}-[4-[2-[(3-cyanophenyl)methoxy]pyridin-3-yl]thiophen-2-yl]-2-(4-ethylsulfonylphenyl)ethanamide, ... (6 entities in total)
• 機能のキーワード: rar-related orphan receptor-g (rorg), transcription, rorg ligand, structure-based design
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35711.99

構造登録者

Xue, Y.,Aagaard, A.,Narjes, F. (登録日: 2017-03-23, 公開日: 2018-08-22, 最終更新日: 2024-01-17)

• 主引用文献: Narjes, F.,Xue, Y.,von Berg, S.,Malmberg, J.,Llinas, A.,Olsson, R.I.,Jirholt, J.,Grindebacke, H.,Leffler, A.,Hossain, N.,Lepisto, M.,Thunberg, L.,Leek, H.,Aagaard, A.,McPheat, J.,Hansson, E.L.,Back, E.,Tangefjord, S.,Chen, R.,Xiong, Y.,Hongbin, G.,Hansson, T.G.; Potent and Orally Bioavailable Inverse Agonists of ROR gamma t Resulting from Structure-Based Design.; J. Med. Chem., 61:7796-7813, 2018; PubMed: 30095900; DOI: 10.1021/acs.jmedchem.8b00783

実験手法

X-RAY DIFFRACTION (1.82 Å)