5NGB

X-Ray Diffraction Crystal Structure of the murine PI3K p110delta in complex with a pan inhibitor

5NGB の概要

• エントリーDOI: 10.2210/pdb5ngb/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 3-[[4-(2-morpholin-4-yl-4-oxidanylidene-3~{H}-quinolin-8-yl)-1,2,3-triazol-1-yl]methyl]benzoic acid (2 entities in total)
• 機能のキーワード: pi3k p110, transferase
• 由来する生物種: Mus musculus (House Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 124744.51

構造登録者

Berndt, A.,Williams, R.L. (登録日: 2017-03-17, 公開日: 2017-09-13, 最終更新日: 2024-01-17)

• 主引用文献: Pirali, T.,Ciraolo, E.,Aprile, S.,Massarotti, A.,Berndt, A.,Griglio, A.,Serafini, M.,Mercalli, V.,Landoni, C.,Campa, C.C.,Margaria, J.P.,Silva, R.L.,Grosa, G.,Sorba, G.,Williams, R.,Hirsch, E.,Tron, G.C.; Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.; ChemMedChem, 12:1542-1554, 2017; PubMed: 28857471; DOI: 10.1002/cmdc.201700340

実験手法

X-RAY DIFFRACTION (2.9 Å)