5NFS
Structure of coxsackievirus B3 3C protease in complex with the alpha-ketoamide (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide (cinnamoyl-phenylalanine-GlnLactam-CO-CO-NH-benzyl)
Summary for 5NFS
Entry DOI | 10.2210/pdb5nfs/pdb |
Descriptor | Genome polyprotein, (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide (3 entities in total) |
Functional Keywords | viral protease, enterovirus, alpha-ketoamide, inhibitor, viral protein |
Biological source | Coxsackievirus B3 |
Cellular location | Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : Q5UEA2 |
Total number of polymer chains | 1 |
Total formula weight | 20998.15 |
Authors | Ma, Q.,Zhang, L.,Hilgenfeld, R. (deposition date: 2017-03-15, release date: 2018-05-16, Last modification date: 2024-05-01) |
Primary citation | Lin, D.,Zhang, L.,Kusov, Y.,Nian, Y.,Ma, Q.,Wang, J.,Leyssen, P.,Lanko, K.,Neyts, J.,de Wilde, A.,Snijder, E.J.,Liu, H.,Hilgenfeld, R. Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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