5NFS

Structure of coxsackievirus B3 3C protease in complex with the alpha-ketoamide (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide (cinnamoyl-phenylalanine-GlnLactam-CO-CO-NH-benzyl)

5NFS の概要

• エントリーDOI: 10.2210/pdb5nfs/pdb
• 分子名称: Genome polyprotein, (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide (3 entities in total)
• 機能のキーワード: viral protease, enterovirus, alpha-ketoamide, inhibitor, viral protein
• 由来する生物種: Coxsackievirus B3
• 細胞内の位置: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : Q5UEA2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20998.15

構造登録者

Ma, Q.,Zhang, L.,Hilgenfeld, R. (登録日: 2017-03-15, 公開日: 2018-05-16, 最終更新日: 2024-05-01)

• 主引用文献: Lin, D.,Zhang, L.,Kusov, Y.,Nian, Y.,Ma, Q.,Wang, J.,Leyssen, P.,Lanko, K.,Neyts, J.,de Wilde, A.,Snijder, E.J.,Liu, H.,Hilgenfeld, R.; Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication; To Be Published,

実験手法

X-RAY DIFFRACTION (1.8 Å)