5NFP

Glucocorticoid Receptor in complex with budesonide

Summary for 5NFP

• Entry DOI: 10.2210/pdb5nfp/pdb
• Descriptor: Glucocorticoid receptor, Nuclear receptor coactivator 2, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ... (7 entities in total)
• Functional Keywords: glucocorticoid receptor, nuclear hormone receptor, steroid receptor, ligand complex, peptide complex, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus : P04150; Nucleus: Q15596
• Total number of polymer chains: 2
• Total formula weight: 35095.64

Authors

Edman, K.,Wissler, L. (deposition date: 2017-03-15, release date: 2017-10-04, Last modification date: 2024-01-17)

• Primary citation: Hemmerling, M.,Nilsson, S.,Edman, K.,Eirefelt, S.,Russell, W.,Hendrickx, R.,Johnsson, E.,Karrman Mardh, C.,Berger, M.,Rehwinkel, H.,Abrahamsson, A.,Dahmen, J.,Eriksson, A.R.,Gabos, B.,Henriksson, K.,Hossain, N.,Ivanova, S.,Jansson, A.H.,Jensen, T.J.,Jerre, A.,Johansson, H.,Klingstedt, T.,Lepisto, M.,Lindsjo, M.,Mile, I.,Nikitidis, G.,Steele, J.,Tehler, U.,Wissler, L.,Hansson, T.; Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.; J. Med. Chem., 60:8591-8605, 2017; PubMed: 28937774; DOI: 10.1021/acs.jmedchem.7b01215

Experimental method

X-RAY DIFFRACTION (2.1 Å)