5NEI
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with JES107
Summary for 5NEI
Entry DOI | 10.2210/pdb5nei/pdb |
Descriptor | Serine/threonine-protein kinase PLK1, 2-[[3-[[5-(3-iodanylphenyl)carbonylthiophen-2-yl]carbonylamino]phenyl]methyl]propanedioic acid (3 entities in total) |
Functional Keywords | plk1, pbd1, mitosis, small molecule, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P53350 |
Total number of polymer chains | 1 |
Total formula weight | 27834.49 |
Authors | Kunciw, D.L.,Rossmann, M.,Stokes, J.E.,De Fusco, C.,Spring, D.R.,Hyvonen, M. (deposition date: 2017-03-10, release date: 2018-02-21, Last modification date: 2024-02-07) |
Primary citation | Kunciw, D.L.,De Fusco, C.,Rossmann, M.,Stokes, J.E.,Renzetti, A.,Sore, H.F.,Hyvonen, M.,Spring, D.R. A fragment-based approach to developing inhibitors of the cryptic pocket of the Polo-Like Kinase 1 Polo-Box Domain. To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
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