5NE1
L2 class A serine-beta-lactamase in complex with cyclic boronate 2
Summary for 5NE1
Entry DOI | 10.2210/pdb5ne1/pdb |
Descriptor | Beta-lactamase, TRIETHYLENE GLYCOL, (4~{R})-4-[[4-(aminomethyl)phenyl]carbonylamino]-3,3-bis(oxidanyl)-2-oxa-3-boranuidabicyclo[4.4.0]deca-1(10),6,8-triene-10-carboxylic acid, ... (4 entities in total) |
Functional Keywords | beta-lactamase, carbapenemase, cyclic boronate, inhibitor, hydrolase |
Biological source | Stenotrophomonas maltophilia (Pseudomonas maltophilia) |
Total number of polymer chains | 2 |
Total formula weight | 59143.77 |
Authors | Hinchliffe, P.,Calvopina, K.,Spencer, J. (deposition date: 2017-03-09, release date: 2017-09-13, Last modification date: 2024-01-17) |
Primary citation | Calvopina, K.,Hinchliffe, P.,Brem, J.,Heesom, K.J.,Johnson, S.,Cain, R.,Lohans, C.T.,Fishwick, C.W.G.,Schofield, C.J.,Spencer, J.,Avison, M.B. Structural/mechanistic insights into the efficacy of nonclassical beta-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. Mol. Microbiol., 106:492-504, 2017 Cited by PubMed: 28876489DOI: 10.1111/mmi.13831 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
Download full validation report