5NDX
The bacterial orthologue of Human a-L-iduronidase does not need N-glycan post-translational modifications to be catalytically competent: Crystallography and QM/MM insights into Mucopolysaccharidosis I
Summary for 5NDX
Entry DOI | 10.2210/pdb5ndx/pdb |
Descriptor | Glycosyl hydrolase, SULFATE ION, (2~{R},3~{S},4~{S},5~{R},6~{S})-6-(4-methyl-2-oxidanylidene-chromen-7-yl)oxy-3,4,5-tris(oxidanyl)oxane-2-carboxylic acid, ... (4 entities in total) |
Functional Keywords | human a-l-iduronidase, mucopolysaccharidosis i, catalytic itinerary, reaction coordinates, catalytic mechanism, n-glycosylation site, rhizobium leguminosarum, iduronidase, hydrolase |
Biological source | Rhizobium leguminosarum bv. trifolii |
Total number of polymer chains | 1 |
Total formula weight | 70640.35 |
Authors | Raich, L.,Valero-Gonzalez, J.,Castro-Lopez, J.,Millan, C.,Jimenez-Garcia, M.J.,Nieto, P.,Uson, I.,Hurtado-Guerrero, R.,Rovira, C. (deposition date: 2017-03-09, release date: 2018-07-11, Last modification date: 2024-05-01) |
Primary citation | Raich, L.,Valero-Gonzalez, J.,Castro-Lopez, J.,Millan, C.,Jimenez-Garcia, M.J.,Nieto, P.,Uson, I.,Hurtado-Guerrero, R.,Rovira, C. The bacterial orthologue of Human a-L-iduronidase does not need N-glycan post-translational modifications to be catalytically competent: Crystallography and QM/MM insights into Mucopolysaccharidosis I. To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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