5NDX

The bacterial orthologue of Human a-L-iduronidase does not need N-glycan post-translational modifications to be catalytically competent: Crystallography and QM/MM insights into Mucopolysaccharidosis I

5NDX の概要

• エントリーDOI: 10.2210/pdb5ndx/pdb
• 分子名称: Glycosyl hydrolase, SULFATE ION, (2~{R},3~{S},4~{S},5~{R},6~{S})-6-(4-methyl-2-oxidanylidene-chromen-7-yl)oxy-3,4,5-tris(oxidanyl)oxane-2-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: human a-l-iduronidase, mucopolysaccharidosis i, catalytic itinerary, reaction coordinates, catalytic mechanism, n-glycosylation site, rhizobium leguminosarum, iduronidase, hydrolase
• 由来する生物種: Rhizobium leguminosarum bv. trifolii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 70640.35

構造登録者

Raich, L.,Valero-Gonzalez, J.,Castro-Lopez, J.,Millan, C.,Jimenez-Garcia, M.J.,Nieto, P.,Uson, I.,Hurtado-Guerrero, R.,Rovira, C. (登録日: 2017-03-09, 公開日: 2018-07-11, 最終更新日: 2024-05-01)

• 主引用文献: Raich, L.,Valero-Gonzalez, J.,Castro-Lopez, J.,Millan, C.,Jimenez-Garcia, M.J.,Nieto, P.,Uson, I.,Hurtado-Guerrero, R.,Rovira, C.; The bacterial orthologue of Human a-L-iduronidase does not need N-glycan post-translational modifications to be catalytically competent: Crystallography and QM/MM insights into Mucopolysaccharidosis I.; To Be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)