5NCQ

Structure of the (SR) Ca2+-ATPase bound to a Tetrahydrocarbazole and TNP-ATP

5NCQ の概要

• エントリーDOI: 10.2210/pdb5ncq/pdb
• 分子名称: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, SPIRO(2,4,6-TRINITROBENZENE[1,2A]-2O',3O'-METHYLENE-ADENINE-TRIPHOSPHATE, POTASSIUM ION, ... (6 entities in total)
• 機能のキーワード: p-type atpase, inhibitory complex, calcium-transporting atpase, hydrolase
• 由来する生物種: Oryctolagus cuniculus (Rabbit)
• 細胞内の位置: Endoplasmic reticulum membrane ; Multi-pass membrane protein : P04191
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 112373.46

構造登録者

Bublitz, M.,Kjellerup, L.,O'Hanlon Cohrt, K.,Gordon, S.,Mortensen, A.L.,Clausen, J.D.,Pallin, D.,Hansen, J.B.,Brown, W.D.,Fuglsang, A.,Winther, A.-M.L. (登録日: 2017-03-06, 公開日: 2018-01-10, 最終更新日: 2024-01-17)

• 主引用文献: Bublitz, M.,Kjellerup, L.,Cohrt, K.O.,Gordon, S.,Mortensen, A.L.,Clausen, J.D.,Pallin, T.D.,Hansen, J.B.,Fuglsang, A.T.,Dalby-Brown, W.,Winther, A.L.; Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity.; PLoS ONE, 13:e0188620-e0188620, 2018; PubMed: 29293507; DOI: 10.1371/journal.pone.0188620

実験手法

X-RAY DIFFRACTION (3 Å)