5NAL

The crystal structure of inhibitor-15 covalently bound to PDE6D

Summary for 5NAL

Entry DOI	10.2210/pdb5nal/pdb
Descriptor	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ~{N}4-[(4-chlorophenyl)methyl]-~{N}1-(cyclohexylmethyl)-~{N}4-cyclopentyl-~{N}1-[(~{Z})-4-[(~{E})-methyliminomethyl]-5-oxidanyl-hex-4-enyl]benzene-1,4-disulfonamide (3 entities in total)
Functional Keywords	lipid binding protein, woodward's reagent k, covalent protein labeling at glutamic acids, arl2 mediated cargo release
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytosol : O43924
Total number of polymer chains	1
Total formula weight	18105.31
Authors	Fansa, E.K.,Martin-Gago, P.,Waldmann, H.,Wittinghofer, A. (deposition date: 2017-02-28, release date: 2017-05-10, Last modification date: 2024-01-17)
Primary citation	Martin-Gago, P.,Fansa, E.K.,Winzker, M.,Murarka, S.,Janning, P.,Schultz-Fademrecht, C.,Baumann, M.,Wittinghofer, A.,Waldmann, H. Covalent Protein Labeling at Glutamic Acids. Cell Chem Biol, 24:589-597.e5, 2017 Cited by PubMed: 28434875 DOI: 10.1016/j.chembiol.2017.03.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation