5NAL

The crystal structure of inhibitor-15 covalently bound to PDE6D

5NAL の概要

• エントリーDOI: 10.2210/pdb5nal/pdb
• 分子名称: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ~{N}4-[(4-chlorophenyl)methyl]-~{N}1-(cyclohexylmethyl)-~{N}4-cyclopentyl-~{N}1-[(~{Z})-4-[(~{E})-methyliminomethyl]-5-oxidanyl-hex-4-enyl]benzene-1,4-disulfonamide (3 entities in total)
• 機能のキーワード: lipid binding protein, woodward's reagent k, covalent protein labeling at glutamic acids, arl2 mediated cargo release
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytosol : O43924
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18105.31

構造登録者

Fansa, E.K.,Martin-Gago, P.,Waldmann, H.,Wittinghofer, A. (登録日: 2017-02-28, 公開日: 2017-05-10, 最終更新日: 2024-01-17)

• 主引用文献: Martin-Gago, P.,Fansa, E.K.,Winzker, M.,Murarka, S.,Janning, P.,Schultz-Fademrecht, C.,Baumann, M.,Wittinghofer, A.,Waldmann, H.; Covalent Protein Labeling at Glutamic Acids.; Cell Chem Biol, 24:589-597.e5, 2017; PubMed: 28434875; DOI: 10.1016/j.chembiol.2017.03.015

実験手法

X-RAY DIFFRACTION (2.2 Å)