5NAH

Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-{5-chloro-6-[(1R)-1-(6-methylpyridazin-3-yl)ethoxy]-1,2-benzoxazol-3-yl}propanoic acid

5NAH の概要

• エントリーDOI: 10.2210/pdb5nah/pdb
• 分子名称: Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, 3-[5-chloranyl-6-[(1~{R})-1-(6-methylpyridazin-3-yl)ethoxy]-1,2-benzoxazol-3-yl]propanoic acid, ... (4 entities in total)
• 機能のキーワード: kmo, oxidoreductase
• 由来する生物種: Pseudomonas fluorescens
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 103869.69

構造登録者

Rowland, P. (登録日: 2017-02-27, 公開日: 2017-06-21, 最終更新日: 2017-07-19)

• 主引用文献: Hutchinson, J.P.,Rowland, P.,Taylor, M.R.D.,Christodoulou, E.M.,Haslam, C.,Hobbs, C.I.,Holmes, D.S.,Homes, P.,Liddle, J.,Mole, D.J.,Uings, I.,Walker, A.L.,Webster, S.P.,Mowat, C.G.,Chung, C.W.; Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.; Nat Commun, 8:15827-15827, 2017; PubMed: 28604669; DOI: 10.1038/ncomms15827

実験手法

X-RAY DIFFRACTION (1.75 Å)