5N7V
TTK kinase domain in complex with MPI-0479605
Summary for 5N7V
Entry DOI | 10.2210/pdb5n7v/pdb |
Descriptor | Dual specificity protein kinase TTK, ~{N}6-cyclohexyl-~{N}2-(2-methyl-4-morpholin-4-yl-phenyl)-7~{H}-purine-2,6-diamine, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, mitosis, mps1, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37239.56 |
Authors | Uitdehaag, J.,Willemsen-Seegers, N.,Zaman, G.J.R. (deposition date: 2017-02-21, release date: 2017-05-31, Last modification date: 2024-01-17) |
Primary citation | Uitdehaag, J.C.M.,de Man, J.,Willemsen-Seegers, N.,Prinsen, M.B.W.,Libouban, M.A.A.,Sterrenburg, J.G.,de Wit, J.J.P.,de Vetter, J.R.F.,de Roos, J.A.D.M.,Buijsman, R.C.,Zaman, G.J.R. Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J. Mol. Biol., 429:2211-2230, 2017 Cited by PubMed: 28539250DOI: 10.1016/j.jmb.2017.05.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.52 Å) |
Structure validation
Download full validation report