5N5I
Crystal Structure of VIM-1 metallo-beta-lactamase in complex with hydrolysed meropenem
Summary for 5N5I
Entry DOI | 10.2210/pdb5n5i/pdb |
Descriptor | Beta-lactamase VIM-1, ZINC ION, (2~{S},3~{R},4~{S})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-(dimethylcarbamoy l)pyrrolidin-3-yl]sulfanyl-3-methyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, ... (4 entities in total) |
Functional Keywords | lactamase, carbapenemase, antibiotic, meropenem, hydrolase |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 1 |
Total formula weight | 27496.46 |
Authors | Salimraj, R.,Hinchliffe, P.,Spencer, J. (deposition date: 2017-02-14, release date: 2018-03-07, Last modification date: 2024-01-17) |
Primary citation | Salimraj, R.,Hinchliffe, P.,Kosmopoulou, M.,Tyrrell, J.M.,Brem, J.,van Berkel, S.S.,Verma, A.,Owens, R.J.,McDonough, M.A.,Walsh, T.R.,Schofield, C.J.,Spencer, J. Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-beta-lactamases. FEBS J., 286:169-183, 2019 Cited by PubMed: 30430727DOI: 10.1111/febs.14695 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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