5N55

mono-Zinc VIM-5 metallo-beta-lactamase in complex with (1-chloro-4-hydroxyisoquinoline-3-carbonyl)-L-tryptophan (Compound 2)

Summary for 5N55

Entry DOI	10.2210/pdb5n55/pdb
Descriptor	Class B metallo-beta-lactamase, ZINC ION, (1-chloro-4-hydroxyisoquinoline-3-carbonyl)-L-tryptophan, ... (4 entities in total)
Functional Keywords	metallo-beta-lactamase, inhibitor, complex, antibiotic resistance, hydrolase
Biological source	Klebsiella pneumoniae
Total number of polymer chains	3
Total formula weight	85775.16
Authors	Li, G.-B.,Brem, J.,McDonough, M.A.,Schofield, C.J. (deposition date: 2017-02-13, release date: 2017-05-17, Last modification date: 2024-01-31)
Primary citation	Li, G.B.,Brem, J.,Lesniak, R.,Abboud, M.I.,Lohans, C.T.,Clifton, I.J.,Yang, S.Y.,Jimenez-Castellanos, J.C.,Avison, M.B.,Spencer, J.,McDonough, M.A.,Schofield, C.J. Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-beta-lactamase inhibition. Chem. Commun. (Camb.), 53:5806-5809, 2017 Cited by PubMed: 28470248 DOI: 10.1039/c7cc02394d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation