5N3S

cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 4-Hydroxybenzamide

5N3S の概要

• エントリーDOI: 10.2210/pdb5n3s/pdb
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, 4-HYDROXYBENZAMIDE, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
• 機能のキーワード: fragment, complex, transferase, serine threonine kinase, camp, kinase, pka
• 由来する生物種: Cricetulus griseus (Chinese hamster)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41723.50

構造登録者

Siefker, C.,Heine, A.,Klebe, G. (登録日: 2017-02-08, 公開日: 2018-02-28, 最終更新日: 2024-01-17)

• 主引用文献: Oebbeke, M.,Siefker, C.,Wagner, B.,Heine, A.,Klebe, G.; Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts.; Angew.Chem.Int.Ed.Engl., 2020; PubMed: 33021032; DOI: 10.1002/anie.202011295

実験手法

X-RAY DIFFRACTION (1.14 Å)