5N3J

cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 4-Nitrobenzoic acid

Summary for 5N3J

Entry DOI	10.2210/pdb5n3j/pdb
Descriptor	cAMP-dependent protein kinase catalytic subunit alpha, (4S)-2-METHYL-2,4-PENTANEDIOL, 4-NITROBENZOIC ACID, ... (5 entities in total)
Functional Keywords	fragment, complex, transferase, serine threonine kinase, camp, kinase, pka
Biological source	Cricetulus griseus (Chinese hamster)
Total number of polymer chains	1
Total formula weight	41635.31
Authors	Siefker, C.,Heine, A.,Klebe, G. (deposition date: 2017-02-08, release date: 2018-02-28, Last modification date: 2024-01-17)
Primary citation	Oebbeke, M.,Siefker, C.,Wagner, B.,Heine, A.,Klebe, G. Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 2020 Cited by PubMed: 33021032 DOI: 10.1002/anie.202011295 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.12 Å)

Structure validation