5N3J
cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 4-Nitrobenzoic acid
Summary for 5N3J
Entry DOI | 10.2210/pdb5n3j/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, (4S)-2-METHYL-2,4-PENTANEDIOL, 4-NITROBENZOIC ACID, ... (5 entities in total) |
Functional Keywords | fragment, complex, transferase, serine threonine kinase, camp, kinase, pka |
Biological source | Cricetulus griseus (Chinese hamster) |
Total number of polymer chains | 1 |
Total formula weight | 41635.31 |
Authors | Siefker, C.,Heine, A.,Klebe, G. (deposition date: 2017-02-08, release date: 2018-02-28, Last modification date: 2024-01-17) |
Primary citation | Oebbeke, M.,Siefker, C.,Wagner, B.,Heine, A.,Klebe, G. Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 2020 Cited by PubMed: 33021032DOI: 10.1002/anie.202011295 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.12 Å) |
Structure validation
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