5N3H

cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule pyridine-3-carboxamide

Summary for 5N3H

Entry DOI	10.2210/pdb5n3h/pdb
Descriptor	cAMP-dependent protein kinase catalytic subunit alpha, NICOTINAMIDE, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	fragment, complex, transferase, serine threonine kinase, camp, kinase, pka
Biological source	Cricetulus griseus (Chinese hamster)
Total number of polymer chains	1
Total formula weight	41550.27
Authors	Siefker, C.,Heine, A.,Klebe, G. (deposition date: 2017-02-08, release date: 2018-02-28, Last modification date: 2024-01-17)
Primary citation	Oebbeke, M.,Siefker, C.,Wagner, B.,Heine, A.,Klebe, G. Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 2020 Cited by PubMed: 33021032 DOI: 10.1002/anie.202011295 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.36 Å)

Structure validation