5N2X

Thermolysin in complex with inhibitor JC272

5N2X の概要

• エントリーDOI: 10.2210/pdb5n2x/pdb
• 分子名称: Thermolysin, ZINC ION, CALCIUM ION, ... (7 entities in total)
• 機能のキーワード: inhibitor, phosphonamidate, protease, hydrolase
• 由来する生物種: Bacillus thermoproteolyticus
• 細胞内の位置: Secreted: P00800
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35411.10

構造登録者

Cramer, J.,Krimmer, S.G.,Heine, A.,Klebe, G. (登録日: 2017-02-08, 公開日: 2017-06-21, 最終更新日: 2024-01-17)

• 主引用文献: Cramer, J.,Krimmer, S.G.,Heine, A.,Klebe, G.; Paying the Price of Desolvation in Solvent-Exposed Protein Pockets: Impact of Distal Solubilizing Groups on Affinity and Binding Thermodynamics in a Series of Thermolysin Inhibitors.; J. Med. Chem., 60:5791-5799, 2017; PubMed: 28590130; DOI: 10.1021/acs.jmedchem.7b00490

実験手法

X-RAY DIFFRACTION (1.209 Å)